LAB ZW
The ZW Lab was established in 2024. Starting with two lab technicians, it has grown into a stable team of approximately 15 members, including exploratory post-doctoral researchers, curious Ph.D. students, and supportive lab technicians. Our research leverages in situ cryo-electron tomography (Cryo-ET) to investigate viral-host interactions within virus-infected host cells. Guided by the principle Mens sana in corpore sano("A healthy mind in a healthy body"), we prioritize both scientific rigor and well-being. While dedicated to advancing research, lab members also actively engage in sports and team building activities to foster collaboration and balance.
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Research
While decades of research have revealed viral entry and fusion mechanisms, post-entry processes-genome release, assembly, and egress-remain poorly understood. This knowledge gap hinders the development of antiviral drugs targeting these stages. To address this, our lab integrates single-particle cryo-EM, cryo-ET, and protein interaction tools to resolve in situ structures of understudied pandemic-potential viruses (e.g., Langya henipavirus, Alongshan virus) and their host interactions. By combining structural biology with immunology and translational platforms, we aim to build a comprehensive antiviral defense strategy against spillover events. We are also developing an ultra-fast cryo-ET sample preparation system to enable time-resolved in situ studies, capturing viral-host interactions at precise timepoints. These advancements will not only clarify viral life cycles but also pioneer methodologies for broader applications in cellular biology.
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Opportunities
The ZW Lab is seeking Ph.D. students, postdoctoral researchers, and lab technicians to join our team! If you’re a passionate, dedicated individual eager to advance cutting-edge research in virology, structural biology, or immunology using state-of-the-art tools like in situ cryo-electron tomography (Cryo-ET) and BSL-3 facilities, we’d love to hear from you. Explore opportunities to contribute to transformative science in a collaborative, innovative environment. For details, visit the Opportunities & Contact section of our website or email us directly. Shape the future of life sciences with us!
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No. 600 Dunyu Road,
XihuDistrict, Hangzhou,
Zhejiang, 310030, P.R. China
Telephone: +86(0)571 8811 1600
No. 18 Shilongshan Road,
Xihu District, Hangzhou,
Zhejiang, 310024, P.R. China
Telephone: +86(0)571 8688 6859
