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In situ cryo-electron tomography (cryo-ET) is a cutting-edge imaging technique that visualizes biological specimens in their native, near-native state at subnanometer resolution. By rapidly freezing samples to preserve cellular architecture (cryo-fixation) and capturing tilted 2D images under an electron microscope, cryo-ET computationally reconstructs 3D volumes of intact cells or organelles. ...
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Cryo-ET data collection and processing pipeline
After a year of lab establishment, we finalized our Cryo-ET data collection and processing pipeline using the Westlake EM facility and our in-house server, which enabled us to observe a healthy mammalian host cell mitochondria in molecular detail with high contrast
Visualized a baculovirus occlusion-derived virus virion entering an occlusion body
Here, we visualized a baculovirus occlusion-derived virus (ODV) virion entering an occlusion body (OB), a process not previously observed at this high resolution. These data demonstrate our ability to capture viral activity within host cells at molecular detail using in situ Cryo-ET
No. 600 Dunyu Road,
XihuDistrict, Hangzhou,
Zhejiang, 310030, P.R. China
Telephone: +86(0)571 8811 1600
No. 18 Shilongshan Road,
Xihu District, Hangzhou,
Zhejiang, 310024, P.R. China
Telephone: +86(0)571 8688 6859
